DM alveolar bone reactive potency decreases in orthodontic tooth movement, weak collagen metabolism. MMP-2 ′ s activity changes regularly, in close relation to bone remodeling, and plays an important role during the orthodontic tooth movement. 在正畸牙齿移动过程中,糖尿病大鼠骨质反应能力降低,胶原代谢较弱,牙齿移动时MMP-2呈规律性变化,与牙齿正畸骨改建关系密切,在牙齿移动中起着重要的作用。